Intraflagellar transport is essential for endochondral bone formation
نویسندگان
چکیده
منابع مشابه
Intraflagellar transport is essential for endochondral bone formation.
While cilia are present on most cells in the mammalian body, their functional importance has only recently been discovered. Cilia formation requires intraflagellar transport (IFT), and mutations disrupting the IFT process result in loss of cilia and mid-gestation lethality with developmental defects that include polydactyly and abnormal neural tube patterning. The early lethality in IFT mutants...
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The highly conserved intraflagellar transport (IFT) proteins are essential for cilia formation in multiple organisms, but surprisingly, cilia form in multiple zebrafish ift mutants. Here, we detected maternal deposition of ift gene products in zebrafish and found that ciliary assembly occurs only during early developmental stages, supporting the idea that maternal contribution of ift gene produ...
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ژورنال
عنوان ژورنال: Development
سال: 2007
ISSN: 1477-9129,0950-1991
DOI: 10.1242/dev.02732